Genetic susceptibility and resistance to tuberculosis
نویسندگان
چکیده
منابع مشابه
KIR-HLA combinations and susceptibility to tuberculosis
Introduction: Tuberculosis (TB), caused by Mycobacterium Tuberculosis (Mtb), with more than nine million new cases and almost two million deaths in each year is a worldwide important public health problem. Generally, human immune responses prevent Mtb spread, and the infection remains in a latent state. Both, innate and adaptive immune responses are involved against TB. However, the role of the...
متن کاملHuman genetic susceptibility to tuberculosis.
INTRODUCTION Recent advances in the understanding of human susceptibility to tuberculosis have resulted from the application of molecular techniques to answer mechanistic questions on genetic regulation of host defense. METHODS This review is based upon a MEDLINE search of articles relevant to human genetic susceptibility to mycobacteria. RESULTS The impact of natural selection in shaping s...
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Background: Susceptibility to disease after infection by Mycobacterium tuberculosis is influenced by environmental and host genetic factors. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of M tuberculosis. This effect may be influenced by polymorphisms at three sites in the vitamin D receptor (VDR) gene. We investigated the interaction between se...
متن کاملHost genetic factors in resistance and susceptibility to tuberculosis infection and disease.
The worldwide public health threat of tuberculosis and the search for novel strategies for preventing and treating disease have focused attention on the interaction between host and pathogen. Despite widespread presence of Mycobacterium tuberculosis, only a relatively small percentage of people exposed to the organism progress to clinical disease. Increasing evidence indicates that host genetic...
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Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...
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ژورنال
عنوان ژورنال: Thorax
سال: 2011
ISSN: 0040-6376
DOI: 10.1136/thoraxjnl-2011-200112